abstract：:We previously reported that Trypanosoma cruzi, the agent of Chagas disease, induces in congenitally infected fetuses a strong, adult-like parasite-specific CD8(+) T cell response producing IFN-γ (Hermann et al. in Blood 100:2153-2158, 2002). This suggests that the parasite is able to overcome the immaturity of neonata...

journal_title：Medical microbiology and immunology

authors： Rodriguez P,Carlier Y,Truyens C

更新日期：2012-05-01 00:00:00

abstract：:Carbapenems are important last-line antibiotics for the treatment of hospital infections. Enterobacteriaceae (such as Klebsiella pneumoniae or Escherichia coli) expressing the "New Delhi Metallo-β-lactamase" gene bla(NDM-1) are resistant to carbapenems and were predicted to become a major global health problem. To cop...

journal_title：Medical microbiology and immunology

authors： Krüttgen A,Razavi S,Imöhl M,Ritter K

更新日期：2011-05-01 00:00:00

abstract：:Monoclonal antibody (MAb) 2c, specific for glycoprotein B of herpes simplex virus (HSV), had been shown to mediate clearance of infection from the mucous membranes of mice, thereby completely inhibiting mucocutaneous inflammation and lethality, even in mice depleted of both CD4(+) and CD8(+) cells. Additionally, gangl...

journal_title：Medical microbiology and immunology

authors： Däumer MP,Schneider B,Giesen DM,Aziz S,Kaiser R,Kupfer B,Schneweis KE,Schneider-Mergener J,Reineke U,Matz B,Eis-Hübinger AM

更新日期：2011-05-01 00:00:00

abstract：:In this study, we presented the construction of a library of expression clones for the herpes simplex virus type 1 (HSV-1) proteome and subcellular localization map of HSV-1 proteins in living cells using yellow fluorescent protein (YFP) fusion proteins. As a result, 21 proteins showed cytoplasmic or subcytoplasmic lo...

journal_title：Medical microbiology and immunology

authors： Xing J,Wang S,Li Y,Guo H,Zhao L,Pan W,Lin F,Zhu H,Wang L,Li M,Wang L,Zheng C

更新日期：2011-02-01 00:00:00

abstract：:The yeast Candida albicans is part of the microflora in most healthy people, but can become a pathogen when host defenses are compromised. The phenotypic plasticity of C. albicans, which includes switching between different morphologies, contributes to its ability to colonize and infect virtually all body locations. A...

journal_title：Medical microbiology and immunology

authors： Morschhäuser J

更新日期：2010-08-01 00:00:00

abstract：:Since the dynamics of transmission of human cytomegalovirus (HCMV) have not been clarified yet, we assessed a possible change in HCMV seroprevalence in Frankfurt am Main, Germany during the past twenty years and tried to detect variables with an impact on epidemiology. Between 1/1/1988 and 10/15/2008, a total of 54443...

journal_title：Medical microbiology and immunology

authors： Lübeck PR,Doerr HW,Rabenau HF

更新日期：2010-02-01 00:00:00

abstract：:Neutrophil extracellular traps (NETs) have recently been discovered as a central part of antimicrobial innate immunity. In the meanwhile, evidence accumulated that NETs are also generated upon non-infectious stimuli in various clinical settings. In acute or chronic inflammatory disorders aberrantly enhanced NET format...

journal_title：Medical microbiology and immunology

authors： Lögters T,Margraf S,Altrichter J,Cinatl J,Mitzner S,Windolf J,Scholz M

更新日期：2009-11-01 00:00:00

abstract：:A coupled luminescent method (CLM) based on glyceraldehyde-3-phosphate dehydrogenase released from injured target cells was used to evaluate the cytotoxicity of antigen-specific HLA class I-restricted CTLs. In contrast to established methods, CLM does not require the pretreatment of target cells with radioactive or to...

journal_title：Medical microbiology and immunology

authors： Ogbomo H,Geiler J,Leutz A,von Kietzell K,Michaelis M,Doerr HW,Cinatl J Jr

更新日期：2009-11-01 00:00:00

abstract：:Quorum sensing system is a cell-to-cell communication system that plays a pivotal role in virulence expression in bacteria. Recent advances have demonstrated that the Pseudomonas aeruginosa quorum sensing molecule, N-3-oxododecanoyl homoserine lactone (3OC(12)-HSL), exerts effects on mammalian cells and modulates host...

journal_title：Medical microbiology and immunology

authors： Li H,Wang L,Ye L,Mao Y,Xie X,Xia C,Chen J,Lu Z,Song J

更新日期：2009-05-01 00:00:00

abstract：:The endogenous danger signal bradykinin was recently found implicated in the development of immunity against parasites via dendritic cells. We here report an essential role of the B(2) (B(2)R) bradykinin receptor in the early immune response against Listeria infection. Mice deficient in B(2)R (B(2)R(-/-) mice) were sh...

journal_title：Medical microbiology and immunology

authors： Kaman WE,Wolterink AF,Bader M,Boele LC,van der Kleij D

更新日期：2009-02-01 00:00:00

abstract：:Gliosis of glial fibrillary acidic protein (GFAP) associated astrocytes is considered to be one of the hallmarks of transmissible spongiform encephalopathies (TSEs). In the present study, remarkable GFAP-PrP(Sc) or GFAP-PrP(C) complexes were separately detected in the brain homogenates of 263 K (Scrapie)-infected or n...

journal_title：Medical microbiology and immunology

authors： Dong CF,Wang XF,Wang X,Shi S,Wang GR,Shan B,An R,Li XL,Zhang BY,Han J,Dong XP

更新日期：2008-12-01 00:00:00

abstract：:In a randomized, placebo-controlled trial in Ghana, 67 onchocerciasis patients received 200-mg/day doxycycline for 4-6 weeks, followed by ivermectin (IVM) after 6 months. After 6-27 months, efficacy was evaluated by onchocercoma histology, PCR and microfilariae determination. Administration of doxycycline resulted in ...

journal_title：Medical microbiology and immunology

authors： Hoerauf A,Specht S,Büttner M,Pfarr K,Mand S,Fimmers R,Marfo-Debrekyei Y,Konadu P,Debrah AY,Bandi C,Brattig N,Albers A,Larbi J,Batsa L,Taylor MJ,Adjei O,Büttner DW

更新日期：2008-09-01 00:00:00

abstract：:Immediate-early (IE) genes are the first genes to be transcribed during the lytic replication cycle of cytomegaloviruses (CMV), and encode nonstructural proteins, which are assumed to have mainly regulatory functions. The IE proteins may play important roles in the pathogenesis of CMV in vivo, for instance during the ...

journal_title：Medical microbiology and immunology

authors： Busche A,Angulo A,Kay-Jackson P,Ghazal P,Messerle M

更新日期：2008-06-01 00:00:00

abstract：:Interactions of virulent Leptospira interrogans with murine monocyte-macrophage-like J774A.1 cells and Vero (African green monkey kidney fibroblasts) cells from attachment to internalization were investigated by a series of morphological analysis. Fontana silver staining revealed that only the pathogenic leptospires w...

journal_title：Medical microbiology and immunology

authors： Liu Y,Zheng W,Li L,Mao Y,Yan J

更新日期：2007-12-01 00:00:00

abstract：:The generation of rodent Plasmodium strains expressing fluorescent proteins in all life cycle stages has had a big impact on malaria research. With this tool in hand, for the first time it was possible to follow in real time by in vivo microscopy the infection route of Plasmodium sporozoites transmitted to the mammali...

journal_title：Medical microbiology and immunology

authors： Sturm A,Heussler V

更新日期：2007-09-01 00:00:00

abstract：:Varicella during pregnancy can be associated with severe illnesses for both the mother and her neonate. Varicella pneumonia must be regarded as a medical emergency, since pregnant women are at risk of life-threatening ventilatory compromise and death. After maternal chickenpox in the first and second trimesters, conge...

journal_title：Medical microbiology and immunology

authors： Sauerbrei A,Wutzler P

更新日期：2007-06-01 00:00:00

abstract：:CAMP factor is an extracellular cytolytic protein produced by Streptococcus agalactiae. CAMP factor has been reported to bind the Fc fragments of immunoglobulin G (IgG) and has therefore also been called protein B, in analogy to protein A of Staphylococcus aureus. We attempted to characterize the interaction of protei...

journal_title：Medical microbiology and immunology

authors： El-Huneidi W,Mui R,Zhang TH,Palmer M

更新日期：2007-06-01 00:00:00

abstract：:Pteridine derivatives neopterin and 7,8-dihydroneopterin are produced by human macrophages and dendritic cells upon stimulation with interferon-gamma (IFN-gamma) and therefore become detectable in increased amounts in humans during cell-mediated (Th1-type) immune response. Compounds produced upon influence of cytokine...

journal_title：Medical microbiology and immunology

authors： Bratslavska O,Platace D,Miklasevics E,Fuchs D,Martinsons A

更新日期：2007-03-01 00:00:00

abstract：:The streptococcal pyrogenic exotoxin B (SpeB) is known to be involved in group A streptococcus (GAS) survival in blood, but the detailed mechanism is not clear. For clarification of this issue, speB isogenic mutants of strains M6 and M49 were constructed by using an integrational plasmid and confirmed by Southern blot...

journal_title：Medical microbiology and immunology

authors： Chiang-Ni C,Wang CH,Tsai PJ,Chuang WJ,Lin YS,Lin MT,Liu CC,Wu JJ

更新日期：2006-06-01 00:00:00

abstract：:We have shown that the P and V proteins of human parainfluenza virus type 2 (hPIV-2) bind to genomic RNA by using Northwestern blot analysis. To identify the RNA-binding regions on the P and V proteins, we used a set of deletion mutants produced in Escherichia coli. One region required for the RNA-binding was found in...

journal_title：Medical microbiology and immunology

authors： Nishio M,Tsurudome M,Ito M,Ito Y

更新日期：2006-03-01 00:00:00

abstract：:Enterocytozoon bieneusi is emerging as an important cause of chronic diarrhoea in AIDS patients. Its reservoirs and transmission patterns are unknown. In this study, we have examined E. bieneusi sequences from four Rhesus macaques of different origin, which were kept at one animal facility. The sequences were identica...

journal_title：Medical microbiology and immunology

authors： Drosten C,Laabs J,Kuhn EM,Schottelius J

更新日期：2005-08-01 00:00:00

abstract：:BALB/c male mice infected with the H3 variant of coxsackievirus B3 (CVB3) develop fulminant myocarditis. Age-matched female mice show little myocarditis due to decreased virus receptor expression on cardiac cells. TNFalpha and IL-1beta levels were increased in males by 3 days after infection. IFNgamma levels increased...

journal_title：Medical microbiology and immunology

authors： Huber SA

更新日期：2005-05-01 00:00:00

abstract：:Adaptation of Borrelia burgdorferi in the vector and vertebrate host is mediated by mechanisms that regulate differential expression of outer surface lipoproteins (Osps). In this study, real time PCR was applied to quantify tissue-specific expression of four linear plasmid (lp54)-encoded (ospA, zs7.a36, zs7.a66 zs7.a6...

journal_title：Medical microbiology and immunology

authors： Lederer S,Brenner C,Stehle T,Gern L,Wallich R,Simon MM

更新日期：2005-01-01 00:00:00

abstract：:Several lines of evidence suggest a viral infection as the initiating event for the development of myocarditis (MC). Especially enteroviruses like coxsackie B3 virus have been shown to induce MC in humans and strains of MC-prone mice after an infection. The further course of the disease is, however, determined not onl...

journal_title：Medical microbiology and immunology

authors： Schwimmbeck PL,Bigalke B,Schulze K,Pauschinger M,Kühl U,Schultheiss HP

更新日期：2004-05-01 00:00:00

abstract：:Oral candidiasis (OC) is a frequent oral manifestation of HIV infection, is a marker disease and occurs as a pseudomembranous, erythematous or rarely hyperplastic variant; angular cheilitis is also seen. Candida albicans is frequently isolated but other species such as C. krusei and C. dublienensis are emerging. Resis...

journal_title：Medical microbiology and immunology

authors： Reichart PA

更新日期：2003-08-01 00:00:00

abstract：:We have examined 118 oral squamous cell carcinomas, 72 oral leukoplakias, 12 cases of cheilitis and 65 of oral lichen planus for the presence of human papillomavirus (HPV) 6/11, 16 and 18 DNA by PCR/Southern blot hybridization. HPV DNA were found in 51/118 carcinomas (43.2%), in 16/72 (22.2%) leukoplakias, 3/12 (25.0%...

journal_title：Medical microbiology and immunology

authors： Ostwald C,Rutsatz K,Schweder J,Schmidt W,Gundlach K,Barten M

更新日期：2003-08-01 00:00:00

abstract：:The essential protein lysyl-tRNA synthetase (LysRS) exists in two unrelated forms, a class I and a class II-type aminoacyl-tRNA synthetase. Comparative genome sequence analysis revealed that Borrelia burgdorferi sensu lato, the etiological agent of Lyme disease, contains a class I-type LysRS, whereas its tick and mamm...

journal_title：Medical microbiology and immunology

authors： Mejlhede N,Monthán A,Theisen M,Ibba M

更新日期：2003-05-01 00:00:00

abstract：:We compared the impact of IL-4 and IL-5 deficiency during the fully permissive infection of BALB/c mice with the rodent filaria Litomosoides sigmodontis. IL-5, in contrast to IL-4, is crucial for the containment of adult worms during short- and long-term infections. IL-5 KO mice allowed development of more larvae into...

journal_title：Medical microbiology and immunology

authors： Volkmann L,Bain O,Saeftel M,Specht S,Fischer K,Brombacher F,Matthaei KI,Hoerauf A

更新日期：2003-02-01 00:00:00

abstract：:A sentinel surveillance system of the public health service for acute respiratory diseases (ARD), especially influenza, has been realized in the Free State of Saxony of Germany for 25 years. The epidemiological sentinel is based on weekly registration of morbidity and mathematical-statistical calculations. For a micro...

journal_title：Medical microbiology and immunology

authors： Bigl S,Briem I,Drechsler R,Kluge D,Müller L,Nowotnik G

更新日期：2002-12-01 00:00:00

abstract：:During normal interpandemic influenza seasons, immune responses to vaccines are quite predictable and meet the licensing criteria of the European Union (EU) Committee for Proprietary Medicinal Products (CPMP). In a pandemic situation, large sections, if not all of the community will be immunologically naïve and theref...

journal_title：Medical microbiology and immunology

authors： Wood JM,Nicholson KG,Stephenson I,Zambon M,Newman RW,Major DL,Podda A

更新日期：2002-12-01 00:00:00

abstract：:Due to its ability to attach to polymeric surfaces Staphylococcus epidermidis is a common pathogen in chronic, medical device-associated infections. Attached S. epidermidis displays reduced susceptibility against a variety of antimicrobial substances, and little correlation between standard susceptibility test results...

journal_title：Medical microbiology and immunology

authors： Knobloch JK,Von Osten H,Horstkotte MA,Rohde H,Mack D

更新日期：2002-10-01 00:00:00

abstract：:Moraxella catarrhalis is an important pathogen of respiratory and middle ear infections. We previously reported that the attachment of M. catarrhalis to pharyngeal epithelial cells is mediated by ganglioside M2 (GM2). Several sets of adhesins or receptors are involved in such attachment process. In this study, we used...

journal_title：Medical microbiology and immunology

authors： Ahmed K,Suzuki Y,Miyamoto D,Nagatake T

更新日期：2002-05-01 00:00:00

abstract：:Convulsions and encephalopathy are common complications of Shiga toxin (Stx)-producing Shigella and enterohemorrhagic Escherichia coli infections. In previous studies, we demonstrated that Stx and lipopolysaccharide (LPS) act in concert to enhance mice sensitivity to pentylenetetrazole (PTZ)-induced seizures via mecha...

journal_title：Medical microbiology and immunology

authors： Yuhas Y,Nofech-Mozes Y,Weizman A,Ashkenazi S

更新日期：2002-03-01 00:00:00

abstract：:A total of 603 serum samples obtained from 12 different patient and control groups, including potentially cross-reactive sera, were tested for the presence of antibodies against Kaposi's sarcoma-associated herpesvirus (KSHV, HHV-8). The assays used were an inhouse immunofluorescence test (IFT) employing latent KSHV an...

journal_title：Medical microbiology and immunology

authors： Preiser W,Szép NI,Lang D,Doerr HW,Rabenau HF

更新日期：2001-12-01 00:00:00

abstract：:This is a summary of the recent work on some glycosidases of sand flies and their Leishmania parasites. Glycosidases catalyze the hydrolysis of complex sugar subunits of polysaccharides into simple sugars. Leishmania major parasites secrete chitinase and N-acetylglucosaminase, which enables them to survive in the gut ...

journal_title：Medical microbiology and immunology

authors： Jacobson RL,Schlein Y,Eisenberger CL

更新日期：2001-11-01 00:00:00

abstract：:The sequencing of Leishmania major Friedlin chromosome 1 (Chr1), Chr3, and Chr4 has been completed. and several other chromosomes are well underway. The complete genome sequence should be available by 2003. Over 1,000 full-length new genes have been identified, with the majority (approximately 75%) having unknown func...

journal_title：Medical microbiology and immunology

authors： Myler PJ,Beverley SM,Cruz AK,Dobson DE,Ivens AC,McDonagh PD,Madhubala R,Martinez-Calvillo S,Ruiz JC,Saxena A,Sisk E,Sunkin SM,Worthey E,Yan S,Stuart KD

更新日期：2001-11-01 00:00:00

abstract：:The present study analyses the susceptibility of human bladder-derived cells (HT-1376) to the infection by herpes simplex virus type 2 (HSV-2) and Chlamydia trachomatis, as well as to the adhesiveness of uropathogenic bacteria. HT-1376 cells were efficiently infected by HSV-2 strain 333, as demonstrated by immunofluor...

journal_title：Medical microbiology and immunology

authors： Superti F,Longhi C,Di Biase AM,Tinari A,Marchetti M,Pisani S,Gallinelli C,Chiarini F,Seganti L

更新日期：2001-09-01 00:00:00

abstract：:The stimulatory effect of lipopolysaccharide (LPS) on human macrophages was found to be neutralized by the detergent octylglucoside (OG). Both macrophage stimulation and reactivity in a limulus amebocyte lysate test were suppressed by suspension of LPS in OG at concentrations between 0.25 and 2.5 mM, whereas other sti...

journal_title：Medical microbiology and immunology

authors： Henrich B,Guadarrama R,Zähringer U,MacKenzie CR

更新日期：2001-04-01 00:00:00

abstract：:In the present study, synthetic peptides (EENVEHDA)2 [(oc)2] and (DDEHVEEPTVA)2 [(un)2] of ring-infected erythrocyte surface antigen (RESA) of Plasmodlium filciparum were linked with palmitic acid and entrapped in immunostimulating complexes (ISCOMs). The immunogenicity of the peptide(s) and mixture of peptides were s...

journal_title：Medical microbiology and immunology

authors： Chopra N,Biswas S,Thomas B,Sabhnani L,Rao DN

更新日期：2000-11-01 00:00:00

abstract：:The present study was designed to determine whether tumor induction by 3-methylcholanthrene (MC), a carcinogenic hydrocarbon, can be inhibited by oral administration of Lactobacillus casei strain Shirota (LC). C3H/HeN mice were divided into four groups and assigned to the following treatments: treated with MC and give...

journal_title：Medical microbiology and immunology

authors： Takagi A,Matsuzaki T,Sato M,Nomoto K,Morotomi M,Yokokura T

更新日期：1999-12-01 00:00:00